Value of positron emission tomography-CT imaging combined with continual detection of CA_(125) in serum for diagnosis of early asymptomatic recurrence of epithelial ovarian carcinoma
- VernacularTitle:正电子发射体层显像-CT检查联合CA_(125)连续检测诊断早期无症状的复发性卵巢上皮性癌的价值
- Author:
Xiu-Gui SHENG
;
Xiao-Ling ZHANG
;
Zheng FU
;
Hui-Qin LI
;
Qing-Shui LI
;
Zhi-Fang MA
;
Da-Peng LI
;
Zhen-Yun CHEN
;
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Neoplasm recurrence;
local;
Tomography;
emission-computed;
CA-125 antigen;
Prognosis
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of positron emission tomography(PET)-CT imaging combined with continual detection of CA_(125)in serum for diagnosis of early recurrent ovarian epithelial carcinoma.Methods Twenty six patients received PET-CT imaging,who were all diagnosed as primary epithelial ovarian cancer of stage Ⅱ-Ⅳ and had complete remission after cytoreductive surgery and multiple courses of chemotherapy in Shandong Provincial Cancer Hospital.After a steady period,all patients experienced progressive rising of CA_(125)values 3 times in 2 months.But no positive lesion was found by CT, or although suspicious positive focus was found,the recurrent and(or)metastatic extent was not definite. Out of 26 patients,16 were delivered rechemotherapy and(or)radiotherapy,and 10 received re- cytoreductive surgery.Results(1)Of 26 patients,the value of CA_(125)was more than 35 kU/L in 17,and in 14 of 17,pelvic or abdominal cavity recurrence was diagnosed by CT and PET-CT,and 4 showed simuhaneously distant metastasis on PET-CT.In the remaining 3 patients of which CT findings were negative,2 had pelvic and abdominal cavity recurrence,and one had bone metastasis on PET-CT.Of 9 patients with progressive rising CA_(125)levels but the value was less than cut-off(
