Correlation of Spleen-stomach Damp-heat Syndrome with Human Leucocyte Antigen Class Ⅱ Gene Polymorphism
- VernacularTitle:脾胃湿热证与人类白细胞抗原Ⅱ类基因多态性的相关性研究
- Author:
Qingqing CHEN
;
Peizheng LIN
;
Ke'Er HUANG
;
Qiuying XU
;
- Publication Type:Journal Article
- Keywords:
SPLEEN-STOMACH DAMP-HEAT SYNDROME;
HUMAN LEUCOCYTE ANTIGEN CLASS Ⅱ;
GENE POLYMORPHISM
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To study the correlation of human leucocyte antigen(HLA) class Ⅱ allele with spleen-stomach damp-heat(SSDH) syndrome.【Methods】From those people with native place of Guangdong,16 healthy volunteers served as the normal control and 46 patients with chronic superficial gastritis or digestive ulceration were enrolled into the observation.Of 46 patients,26 were classified into SSDH and 20 into spleen deficiency(SD) syndrome.HLA-DRB1,HLA-DQA1,HLA-DQB1,and HLADPB1 alleles of HLA class Ⅱ from whole blood sample were analyzed by the method of polymerase chain reaction-sequence specific primers(PCR-SSP).【Results】The gene frequency of DQA1*0103 in SSDH group was remarkably higher than that in the normal control group(P
