Experiment study of intervertebral fusion cage made by a new biomimetic grafting material
- VernacularTitle:新型生物活性椎间融合器的实验研究
- Author:
Yong LIANG
;
Dianming JIANG
;
- Publication Type:Journal Article
- Keywords:
Nano-hydroxyapatite;
Ployamide66;
rhBMP-2;
Interverbral cage;
Cervical vertebral fusion;
Goats
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the characteristics of fusion using biomimetic n-HA/PA66 interbody cage with rhBMP-2 and discuss the feasibility of it.Methods:Thirty adult female goats underwent C_(3-4) discectomy and interverbral fusion performed with nHA/PA66 interbody cage without rhBMP-2(n=10).nHA/PA66 interbody cage with rhBMP-2(n=10),autogenous iliac crest bone graft(n=10).X ray was carried out at 4 and12 weeks after surgery to evaluate fusion quality.The goats were killed respectively on the 12th week.Nondestructive biomechanical testing for stiffness,un-decalcified histology were performed.Result:The goats in the n-HA/PA66 with rhBMP-2 group and the autogrft group all showed complete fusion at 12th week.there was no statisti- cally significant differience between the n-HA/PA66 with rhBMP-2 group and the autogrft group upon biomechanics,radiography and histomorphology.Conclusion:The interverbral fusion cage with n-HA/PA66 has good hiocompatibifity and osteoconductive ability and it may be good osteoionductive with rhBMP-2,so it was one ideal interbody fusion cage.
