Study of the expression and value of CXCRI and CXCR2 in ankylosing spondylitis
- VernacularTitle:白细胞介素-8受体A型和B型在强直陛脊柱炎中的表达及其意义探讨
- Author:
Wei-Zhen HE
;
Jie-Ruo GU
;
Ze-Tao LIAO
;
Qiu-Jing WEI
;
Qu LIN
;
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Receptors,interleukin-8A;
Receptors,interleukin-8B
- From:
Chinese Journal of Rheumatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and value of CXCR1 and CXCR2 on neutrophils, CD14~+ monocytes and CD3~+ T lymphocytes of peripberol blood of ankylosing spondylitis(AS)patients and to investigate the correlation between CXCR1,CXCR2 and disease activity.Methods A case control study was designed and enrolled 30 active AS,30 active rheumatoid arthritis(RA)and 30 healthy controls.The levels of CXCR1 and CXCR2 expression on neutrophils,CD3~+ T cells and CD14~+ monocytes of peripheral blood of the patients and healthy controls enrolled were measured and analyzed by flow cytometry by measuring the mean fluorescence intensity(MFI)channel.The correlations between the level of CXCR1 and CXCR2 anti disease activity or functional index of AS such as BASDAI,BASF1,ESR and CRP were analyzed.Results The MFI of CXCR1 expression on CD3~+ T lymphocytes of peripheral blood was significantly higher in AS patients (41?24)than that in RA patients(18?10)and healthy controls(19?7)(P
