Effects of 75 gram glucose oral tolerance test and standard meal test on insulin secretion function of islets of Langerhans and free fatty acid in patients with type 2 diabetes mellitus
- VernacularTitle:75g葡萄糖耐量和标准餐对2型糖尿病患者胰岛功能和游离脂肪酸的影响
- Author:
Qi SUN
;
Jing-Bo ZENG
;
Kang YU
;
Yu-Xiu LI
;
Qiu-Ying LIU
;
Wei QIN
;
Qing-Rong PAN
;
Heng WANG
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type two;
Pancreatic function;
Glucose tolerance test;
Free fatty acids
- From:
Chinese Journal of General Practitioners
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of 75 gram glucose oral tolerance test (75 g OGTT) and standard mixed meal test (SMMT) on insulin secretion function of the islets of Langerhans and plasma free fatty acid (FFA) in patients with type 2 diabetes mellitus.Methods Seventy-six patients with type 2 diabetes without using insulin and with no obvious complications were recruited for 75 g OGTT following overnight fasting on the first day and SMMT (bread 50 g,egg 50 g and milk 250 ml) on the 7th day.Blood specimens were collected from each patients before the tests and 30 min,60 min,120 min and 180 min after glucose or meal load to measure their levels of plasma glucose,serum insulin,C peptide,FFA and lipids (total cholesterol,triglyceride,high-density and low-density lipoprotein cholesterol).Results No difference in fasting plasma glucose,serum insulin,C peptide,FFA and lipids between 75 g OGTT and SMMT was found.Postprandial plasma glucose 30 min,60 min,120 min and 180 min after 75 g OGTT was significantly higher than that after SMMT,with (15.3?3.5) vs (9.9?3.4) mmol/L,(18.2?4.8) vs (12.8?4.0) mmol/L,(16.3?5.8) vs (12.2?4.9) mmol/L and (10.6?5.4) vs (9.5?4.5) mmol/L (F=28.1,P
