Changes of serum cytokeratin 19 fragment in postoperative patients with non-small cell lung cancer
- VernacularTitle:血清角蛋白19片段在非小细胞肺癌患者术后的变化
- Author:
Yong-Xin ZHOU
;
Yong-Wu WANG
;
Yun-Qing MEI
;
Jing FENG
;
Jian-Zhi CAI
;
Yi-Feng SUN
;
Qiang JI
;
Da-Wen LI
;
- Publication Type:Journal Article
- Keywords:
Lung neoplasma;
Carcinoma,non-small cell lung;
Tumor markers,biological
- From:
Chinese Journal of General Practitioners
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of serum cytokeratin 19 fragment (CYFRA21-1) as a biomarker in evaluating its prognosis,monitoring and follow-up of the postoperative patients with non- small cell lung cancer (NSCLC).Methods Serum CYFRA21-1 was determined by radioimmunoassay for 207 patients with NSCLC before and after surgical operation at Tongji Hospital,Shanghai.Relationship between serum CYFRA21-1 and the prognosis,recurrence and metastasis of lung cancer was analyzed retrospectively.Results The patients were followed-up for 37 months in average.Preoperative serum CYFRA21-1 was positive in 42.0% (87/207) of all the cases,48.8% (60/123) of squamous cell earcinama and 34.6% (27/78) of adenocarcinoma,with statistical significance (X~2=3.901,P
