Study of the mechanism of mast cell increase in cellular leiomyoma of uterus
- VernacularTitle:子宫富于细胞平滑肌瘤中肥大细胞增加的机制研究
- Author:
Jie-Qiang LV
;
Xue-Qiong ZHU
;
Ke DONG
;
Mei XIANG
;
Yi LIN
;
Yue HU
;
- Publication Type:Journal Article
- Keywords:
Uterine neoplasms;
Leiomyoma;
Mast cells;
Chemotactic factors
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of mast cell increase in cellular leiomyoma of uterus.Methods Tissue sections from 30 cases of cellular leiomyoma of uterus,15 cases of leiomyosarcoma and 30 cases of ordinary leiomyoma were studied using immunohistochemical double labeling techniques.The expression of mast cell tryptase ahd Ki-67 as well as mast cell tryptase and chemotactic factors RANTES,Eotaxin,monocyte chemoattractant protein-1(MCP-1),transforming growth factor-? (TGF-?)were double immunostained.Results Ki-67 in mast cells was rarely expressed in each group. Expressions of regulate upon activation normal T cell expressed and secreted(RANTES),Eotaxin and TGF-? in cellular leiomyoma were 78%,89%,91%,respectively.They were all higher than those in ordinary leiomyoma and leiomyosarcoma(P
