Study of the Morbid Risk Factors of Chronic Tubulointerstitial Nephropathy with an Unknown Origin in Wenzhou City
- VernacularTitle:温州市不明原因慢性小管间质性肾病危险因素分析
- Author:
Fan LIN
;
Feifei XU
;
Yinqiu LV
;
Yi LIU
;
- Publication Type:Journal Article
- Keywords:
Chronic tubulointerstitial nephropathy;
Risk factor;
Case-control Study;
Caulis aristolochiae manshuriensts;
Aristolochic acid
- From:
Chinese Journal of Pharmacoepidemiology
2007;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the morbid risk factors of chronic tubulointerstitial nephropathy(CTN)with an unknown origin in Wenzhhou City.Method:810 residents in several big districts were investigated.652 subjects,which had complete data and were coincided with the inclusion standard,were analyzed by an unmatched case-control study.The case group contained 19 cases coincided with the diagnostic criteria for CTN with unknown causes.The controlled group contained 633 cases.Thirteen probable risk factors were selected to be investigated:age,sex,body height,body weight, occupation,education,allergic history,addiction to smoking or wine,family history,the respective exposure to heavy met- als,radioactive ray and poisons.A history of medications,including caulis aristolochiae manshuriensis,antipyretic analge- sic,antibiotics,etc.was also investigated.The odds ratio(OR)of CTN with an unknown origin caused by risk factors were calculated with Logistic regression analysis.The obtained data were investigated,and the risk factors were screened out. All the data were analyzed with SPSS 12.0.Result:The homogeneity test showed there was no significant difference in age, sex,occupation and education between the case and controlled groups.The exposure to heavy metals or caulis aristolochiae manshuriensis was screened as the valid risk factor of CTN with OR 17.50 and 103.594 respoetively(P
