Clinical characteristics of 115 Chinese patients with antiphospholipid syndrome and the analysis of different classification criteria
- VernacularTitle:抗磷脂综合征115例的临床特点及临床分类标准的演变和局限性的探讨
- Author:
Jie QIAN
;
Xiao-Xiang CHEN
;
Shu-Jie LI
;
Mei-Fang WU
;
Ting ZENG
;
Yu-Qiong ZOU
;
Yue-Ying GU
;
Yuan WANG
;
Chun-De BAO
;
Shunle CHEN
;
Chengde YANG
;
- Publication Type:Journal Article
- Keywords:
Antiphospholipid syndrome;
Thrombosis;
Antibodies, Anticardiolipin;
Glycoproteins;
Lupus coagulation inhibitor
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze three different classification criteria, the clinical characteristics of antiphospholipid syndrome(APS)in a cohort of Chinese patients. Methods From January 1996 to October 2006, APS patients diagnosed with different classification criteria were retrospectively studied. Results There were totally 120 APS patients fulfilled at least one criterion, One hundred and one patients fulfilled the 1988 Asherson criteria, 96 patients fulfilled the 1999 Sapporo criteria, and 115 patients fulfilled the 2006 Sydney criteria. The ratio of male to female in a cohort of 115 definite APS patients was 1 to 10.5. The mean period of the disease until entry into the study was 82.6 months, the mean age at study entry was(41?12)years. Ninety patients had thrombosis episodes, among which the most common presenting manifestations were deep venous thrombosis, stroke and skin vasculitis. Forty-six of 92 married women in our cohort had fetal morbidity. Catas- trophic APS occurred in 7 patients. The presence of anticardiolipin antibodies(aCL)was detected in 86 pa- tients, anti-beta-2 glycoproteinⅠantibodies in 58 patients and lupus anticoagulant(LA)in 27 patients. Conclusion The most common presenting manifestations are deep venous thrombosis, stroke and cutaneous manifestations. The sensitivity of Sydney classification criteria is improved by adding anti-beta-2 glycopreteinⅠantibody as one of the laboratory criteria. However, primary APS patients who only presented with thrombo- cytupenia and positive laboratory tests could not satisfy this criterion. In addition, the significance of autoanti- bodies to some coagulant factors in APS needs further study.
