The association between ankylosing spondylitis with polymorphism in -308 site of TNF-?promoter region:the Meta analysis
- VernacularTitle:强直性脊柱炎与肿瘤坏死因子-?基因启动子-308位点多态性关联研究的Meta分析
- Author:
Qing-Rui YANG
;
Yuan-Chao ZHANG
;
Hong-Sheng SUN
;
Kun MU
;
- Publication Type:Journal Article
- Keywords:
Spondylitis, ankylosing;
Meta analysis;
Polymorphism(genetics)
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between ankylosing spondylitis(AS)with the poly- morphism in -308 site of tumor necrosis factor(TNF)-?promoter region. Methods The literature about AS and polymorphism in -308 site of TNF-?promoter region were searched and the meta analysis as performed. Results Eight studies enrolled 987 AS patients and 922 controls in total. The analysis showed that the fre- quencies of alleles and the genotypes had no statistical difference between AS group and the control group [OR=0.86(0.53, 1.38), P=0.53; OR=0.90(0.52, 1.55), P=0.69]. But the frequencies of alleles of western origin had statistical difference between AS group and the control group [OR=0.75(0.59, 0.96), P=0.02]; The TNF-?gene promoter polymorphism may play a role in the severity of sacroiliitis[OR=0.37(0.15. 0.90), P=0.03]. Conclusion The meta-analysis reveales that the alleles of -308 site of TNF-?promoter region may be associated with AS in western ethnical group and play a role in the severity of saeroiliitis.
