Effects of Ulinastatin and 1, 6 fructose diphosphate on GSH-Px and MDA in cerebral ischemia-reperfusion injury
- VernacularTitle:乌司他丁与1，6二磷酸果糖对脑缺血-再灌注谷胱甘肽过氧化物酶和丙二醛影响
- Author:
Jian ZHANG
;
Sheng-Tao YAN
;
Shi-Dong GUO
;
Li-Da ZHI
;
- Publication Type:Journal Article
- Keywords:
Ischemia-reperfusion injury;
Ulinastatin;
1,6 fructose diphosphate
- From:
Chinese Journal of Emergency Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of Ulinastatin (UTI) and 1, 6 fructose diphosphate (FDP) on cerebral ischemia-reperfusion injury, and to discuss the protective mechanisms of UT1 and FDP on cerebral ischemia-repeffusion injury. Method Rabbit ischemia-repeffusion injury models were prepared by"four arteries occlusion". All rabbits were divided into four groups (n=6): control group, UTI (10 U/kg) group, FDP (200 mg/kg) group, UTI+ FDP group. Salt water, UTI, FDP and UTI + FDP were respectively used immediately after ischemia-reperfusion. Plasmic MDA and GSH-Px were measured at 30 minutes, 1 hour, 3 hours and 6 hours after reperfusion. Results The concentrations of plasmic MDA in every group were significantly improved compared with those in control group (P0.05 ), but significant difference could be found after 3 hours (P
