Study of animal model of hypertensive disorder complicating pregnancy in pregnant rats stimulated by homocysteine and monosodinm glutamate
- VernacularTitle:同型半胱氨酸与谷氨酸联合诱发孕鼠妊娠期高血压疾病的实验研究
- Author:
Jun WANG
;
Ju LI
;
Hong CHEN
;
Yu-Zhen DONG
;
Li-Jiang ZHANG
;
Jing GE
;
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
cardiovascular;
Hypertension;
Homocysteine;
Sodium glutamate;
Disease models;
animal
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether homocysteine(Hcy)and monosodium glutamate (MSG)could lead to animal model of hypertensive disorder complicating pregnancy and its mechanism. Methods Female adult Wistar rats were randomly divided into 4 groups:pregnant control group(PN), pregnant Hcy group(PH),pregnant glutamic acid group(PG)and pregnant Hcy and glutamie acid group (PHG).The rats of each group were injected with Hey 200 mg/kg or physiological saline every day intraperitoneally and with MSG or 0.9% saline every other day via Hcy injection from the 10th day to the 20th day of pregnancy.The blood pressure,urine protein,function of liver and kidney,weight of placenta, length and weight of fetus were all measured.The histological change of the pallium and the change of behavior of pregnant rats were also observed.Results(1)The blood pressure in PH[(107?8)mm Hg, 1 mm Hg=0.133 kPa],and PHG group [(109?10)mm Hg] after the treatment increased significantly compared with those in other groups from the 12 th day after pregnancy(P
