Expression of phosphorylated protein kinase B and PTEN protein in ovarian epithelial cancer
- VernacularTitle:卵巢上皮性癌组织中磷酸化蛋白激酶B和PTEN蛋白的表达及其意义
- Author:
Yu-Huan QIAO
;
Jia CHENG
;
Rui-Xia GUO
;
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
PTEN phosphohydrolase;
Proto-oncogene proteins c-akt;
Prognosis
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of phosphorylated protein kinase B(pAKT)and PTEN protein in ovarian epithelial cancer and to investigate the correlations between their expression and prognosis of ovarian epithelial cancers.Methods Expression of pAKT and PTEN in 12 normal ovarian tissues,20 benign tumors,12 borderline tumors and 80 cases of ovarian epithelial cancers were detected by immunohistochemical method,and their correlations were analyzed.Results The positive expression of pAKT in normal ovarian and benign tumor tissues were significantly lower than that in ovarian epithelial cancers(8%,10% vs 55%;P
