The expression and significance of cyclooxygenase-2 and matrix metalloproteinase-2 protein in human gastric carcinoma
- VernacularTitle:基质金属蛋白酶-2和环氧合酶-2在胃癌中的表达及意义
- Author:
Lei GONG
;
Ming XU
;
Xiao-Bing PENG
;
Xuejun TANG
;
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Cyclooxygenase 2;
Gelatinase
- From:
Chinese Journal of Digestion
1996;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protein expression of cyclooxygenase(COX)-2 and matrix metalloproteinase(MMP)-2 and their correlation in human gastric carcinoma.Methods The protein expression of COX-2 and MMP-2 was determined by immunohistochemistry in tumor tissues and adjacent cancerous tissues (3 cm and 6 cm away from tumor margin) of 30 patients with gastric cancer,and in gastric mucosa of 10 healthy individuals.Results Expression of COX-2 was found in cancer cells of 26 out of 30 cases (86.67%),which was significantly higher than that in normal control (0 of 10,P
