Effect of Acupuncture Combined with TAX on the Expression of Apoptosis Related Factor p53 and bcl-2 of Mice Lewis Lung Cancer Cells
- VernacularTitle:针刺联合紫杉醇对小鼠Lewis肺癌细胞凋亡相关因子p53、bcl-2蛋白表达的影响
- Author:
Ze-Dong CHENG
;
Yi-Guo CHEN
;
- Publication Type:Journal Article
- Keywords:
combination of acupuncture and medication;
TAX;
p53;
bcl-2;
Lewis cancer;
co-operating effect
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective We adopt acupuncture associating with TAX,to investigate the anti-cancer effect and mechanism.Methods 48 mice with inoculated Lewis Lung Carcinoma were divided randomly into 4 groups:model group,acupuncture group,medicine group,combination of acupuncture and medicine group.Growth state of the mice and change curve of tumour.Protein expression of apoptosis related factor p53 and Bc1-2 in tumour were observed by Western Blotting method.Results Acupuncture,TAX and the combination of acupuncture and TAX separately had anti-tumor effect,with the combination was the best and improve growth state of the mice.p53 and bc1-2 can be detected in four groups.Compared with model group,the expression of other groups was lower.Compared with acupuncture group and medicine group, the exprission of combination group of acupuncture and TAX was lower.Conclution Combination of acupuncture and TAX can prohibit p53 Mutant and decrease Bcl-2,which have co-operating effect.
