Marchiafava Bignami Disease Potentially Complicating Normal Pressure Hydrocephalus.
10.12779/dnd.2014.13.1.24
- Author:
Sanghak LEE
1
;
Insub YOO
;
Kyung Hoe LEE
;
Hyun Duk YANG
Author Information
1. Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunpo, Korea. hyundyang@gmail.com
- Publication Type:Case Report
- Keywords:
Marchiafava-Bignami disease;
Normal pressure hydrocephalus;
Complication
- MeSH:
Alcohol Drinking;
Cerebrospinal Fluid;
Corpus Callosum;
Demyelinating Diseases;
Female;
Gait;
Humans;
Hydrocephalus, Normal Pressure*;
Magnetic Resonance Imaging;
Malnutrition;
Marchiafava-Bignami Disease*;
Middle Aged;
Necrosis;
Negotiating;
Tumor Necrosis Factor-alpha;
Urinary Incontinence;
Ventriculoperitoneal Shunt
- From:Dementia and Neurocognitive Disorders
2014;13(1):24-26
- CountryRepublic of Korea
- Language:English
-
Abstract:
Marchiafava-Bignami disease (MBD) is a rare disorder of demyelination or necrosis of the corpus callosum. Mainly, MBD is associated with alcohol and malnutrition. We report a 60-year-old woman with no history of alcohol consumption or malnutrition who had MBD as a possible complication of normal pressure hydrocephalus (NPH). The patient presented with a 2-month history of progressive gait unsteadiness, urinary incontinence, and forgetfulness, for which the patient underwent ventriculoperitoneal shunt surgery with remarkable improvement. Magnetic resonance imaging (MRI) demonstrated hyperintensity in the body and splenium of corpus callosum when she was brought to the hospital again with rapid deterioration of her mental ststus. It might be postulated that cerebrospinal fluid (CSF) tumor necrosis factor-alpha (TNF-alpha) might have contributed to the development of MBD although not measured in this patient, given that TNF-alpha, as a proinflammatory cytokine mediating demyelinating process have been found in be increased in the CSF of NPH.
