The protective effect on joint destruction of ~99Tc-MDP and its effect on tumor necrosis factor alpha in rat collagen-induced arthritis
- VernacularTitle:~(99)Tc-亚甲基二膦酸盐对大鼠胶原诱导性关节炎骨质破坏的抑制作用及其对TNF-?的影响
- Author:
Ya-Ou ZHOU
;
Xiao-Xia ZUO
;
Hui LUO
;
Xian-Zhong XIAO
;
Yi-Sha LI
;
- Publication Type:Journal Article
- Keywords:
Arthritis;
rheumatoid;
Tumor necrosis factor-alpha;
Bone erosion
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of~(99)Tc-MDP on joint inflammation and bone destruc- tion in collagen-induced arthritis(CIA)rats model and its effect on tumor necrosis factor alpha(TNF-?). Methods CIA was induced by immunization of male SD rats with an emulsion of collagen.~(99)Tc-MDP or placebo was intravenous infused to rats for 20 days.Joint inflammation was assessed by arthritis index.Lesions of bone were assessed based on the histological changes in ankle joints,radiographic analysis in hind paw with Larsen score.Systemic TNF-?level was measured by radioimmune assay.Results~(99)Tc-MDP suppressed joint swelling(P
