Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in salivary glands of patients with Sj(?)gren's syndrome
- VernacularTitle:细胞间黏附分子-1和淋巴细胞功能相关抗原-1在干燥综合征发病中的作用
- Author:
Jin-Hua SHI
;
Yun-Xia WU
;
Lian-Ping YANG
;
- Publication Type:Journal Article
- Keywords:
Sjgren's syndrome;
Salivary glands;
Cell adhesion molecules;
Lymphocyte functionassociated antigen-1
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of intercellular adhesion molecule-1(ICAM-1)and lym- phocyte function-associated antigen-I(LFA-1)in the pathogenesis of Sjgren's syndrome(SS)and provide a theoretical basis for clinical therapy.Methods Immunohistochemical method was used to detect these two cellular adhesion molecules in labial salivary glands of primary Sjgren's syndrome patients and 15 healthy controls.Semiquantitative analysis was performed by image analysis software.Results①In salivary gland samples,the expression of both ICAM-1 and LFA-1 was significantly higher compared to that of controls(P
