Study of acute lung Injury in rats with acute carbon monoxid poisoning(ACOP)
- VernacularTitle:急性一氧化碳中毒大鼠急性肺损伤的实验研究
- Author:
Pan ZHANG
;
Jian-Hong LIU
;
Pan-Lin HU
;
Ning LUO
;
Cong-Fang GUO
;
- Publication Type:Journal Article
- Keywords:
Acute carbon monoxid poisoning;
Carbon monoxide hemoglobin;
Arterial oxygen pressure;
Oxygenation index;
Acute respiratory distress syndrom
- From:
Chinese Journal of Emergency Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To structure the model of acute carbon monoxid poisoning(ACOP)in rats. Evaluate the effectiveness of the poisoning on the pulmonary function and the significance of carbon monoxide hemoglobin(HbCO)and oxygenation index in diagnosis of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS).Method Eighty healthy adult male Wistar rats were randomized into 4 groups.According to the concentration of CO,poisoning group was randomized into three groups(each group=20),group A,group B,group C.After poisoned,arterial blood was collected rapidly for arterial blood gas analysis.According to the pathological changes,the models were divided into ALI/ARDS group and non-ALI/ARDS group.Results Compared with control group,the incident rate of ALI/ARDS in group B(25%)and group C(55%)were significantly higher(P
