Thalidomide inhibits the expression of hypoxia-inducible factor-1?in synovial tissues of rats with collagen-induced arthritis
- VernacularTitle:沙利度胺抑制大鼠胶原诱导关节炎滑膜组织缺氧诱导因子-1?的表达
- Author:
Zhong WU
;
Jing LI
;
- Publication Type:Journal Article
- Keywords:
Rats;
Arthritis;
Synoviamembrane;
Hypoxia-induciblefactor-1?;
Thalidomide
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of thalidomide(Thd)on rheumatoid arthritis and its relation with the expression of hypoxia-inducible factor-1?(HIF-1?).Methods Female SD rats were randomly divided into two groups:a normal group and a model group.Each group was further divided into three subgroups:the control group,the vehicle group and the Thd group.The model group was subjected to collagen-induced arthritis.The Thd group and the vehicle group were given Thd(600 mg/kg)once daily and its vehicle DMSO respectively.The profile of arthritis was assessed by observing the clinical symptoms and histopathology and a qualitative clinical score of arthritis.The expression of HIF-1?in synovial tissuses was further detected by Western blot and immunohistochemistry technics.Results Compared to the control group with arthritis,clinical signs and pathological changes of arthritis were improved one and two weeks after ad- ministration of Thd respectively,and the qualitative clinical score of arthritis was evidently lowered.The ex- pression of HIF-1?in the inflammed synovial tissuses was found to be enhanced(P
