Predictive value of soluble vascular endothelial growth factor receptor 1 for preeclampsia in second-trimester
- VernacularTitle:血浆可溶性血管内皮生长因子受体1水平变化对子痫前期发病的早期预测价值
- Author:
Qian CHEN
;
Yun ZHAO
;
Li ZOU
;
Ze-Hua WANG
;
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor receptor-1;
Pre-eclampsia;
Pregnancy outecome
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive value of plasma levels of soluble vascular endothelial growth factor receptor 1(VEGFR-1,also known as sFlt-1) in second-trimester for preeclampsia.Methods One hundred and forty-six pregnant women with normal blood pressure previously were prospectively included in the study.Peripheral venous blood samples were obtained between 20 and 26 gestational weeks.Plasma levels of sFh-1 were measured by an enzyme-linked immunoassay.Results (1) Among 146 previously normotensive women,12 developed preeclampsia (preeclampsia group), 134 remained normal pregnant till the end (normal group).(2) The plasma levels of sFh-1 in preeclampsia group [(4135?699)ng/L] was significantly higher than that in normal group[(1490?1033)ng/L](P
