Relationship between three thrombophilic gene mutations and unexplained recurrent early spontaneous abortion
- VernacularTitle:亚甲基四氢叶酸还原酶、凝血因子Ⅴ和凝血酶原基因多态性与原因不明复发性早期流产的关系
- Author:
Li XU
;
Xiao-Man LIU
;
Hong-Yan ZHANG
;
Jing ZHAO
;
Qi-Wei QI
;
Yun-Fei CHANG
;
- Publication Type:Journal Article
- Keywords:
Abortion;
habitual;
Methylenetetrahydrofolate reductase(NADPH2);
Factor V;
Prothrombin;
Polymorphism (genetics)
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of methylenetetrahydrofolate reductase (MTHFR)gene C677T,factor V(FV)gene G1691A and prothrombin(PT)gene G20210A polymorphisms to unexplained recurrent early spontaneous abortion(URESA).Methods One hundred and twelve patients with URESA and 100 women with at least 1 normal pregnancy and without any miscarriage were analyzed for MTHFR,FV and PT gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results MTHFR gene T/T genotype and T allele frequencies were increased in URESA patients[38.4%(43/112)and 59.8%(134/224)]versus controls[18.0%(18/100)and 43%(43/100),P
