Analysis of the expression of matrix metaUoproteinase and tissue inhibitor of metalloproteinase in gestational trophoblastic diseases
- VernacularTitle:基质金属蛋白酶及其抑制物在妊娠滋养细胞疾病中的表达分析
- Author:
Shu-Zhen DAI
;
Ling-Zhi WANG
;
Yu-Jun LI
;
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Tissue inhibitor of metalloproteinases;
Trophoblastic neoplasms;
Immunohistochemistry
- From:
Chinese Journal of General Practitioners
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) in gestational trophoblastie diseases and its invasiveness.Methods The expression and distribution of MMP-7,MMP-9,TIMP-1 and TIMP-2 were determined by immunohistochemistry PV-6000 in 49 cases of hydatidiform mole (eight of them with malignant transformation),six cases of invasive hydatidiform mole,two cases of choriocarcinoma and 18 cases with normal villi in early pregnancy.Results The expression of MMP-7,MMP-9,TIMP-2 and MMP- 9/TIMP-1 was significantly higher in choriocareinoma,invasive mole and malignant transformed mole than that in normal villi in early pregnancy and non-malignant transformed mole (F=10.950,7.760,7.304, 3.442;P
