Local transplantation of endothelial progenitor cells to reduce restenosis after angioplasty in rabbit model
- VernacularTitle:血管内皮祖细胞局部移植防治血管内皮损伤后再狭窄形成的实验研究
- Author:
Zhan-Long MA
;
Gao-Jun TENG
;
Xiao-Li MAI
;
Sheng-Hong JU
;
Jun-Hui SUN
;
Jun CHEN
;
Hong-Ying ZHANG
;
Hong-Jian SHI
;
Hui YU
;
Guozhao LI
;
- Publication Type:Journal Article
- Keywords:
Endothelial progenitor cells;
Restenosis;
Cells transplantation;
Rabbits
- From:Journal of Interventional Radiology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate homografting vascular endothelial progenitor cells(EPCs)for preventing restenosis formation of carotid artery in New Zealand white rabbit models.Methods EPCs of New Zealand white rabbits were isolated,confirmed and expanded though the injured carotid arterial endothelium of rabbit model induced by dilatation with a 2.5 F balloon;and then EPCs were transplanted into the injured endothelium of the cells transplantation group(n=13,3 of them were transplanted with fluorencently-labeled- EPCs),while equal volume of saline without EPCs was injected into the injured endothelium in the control group(n=8).Histopathology was performed at 4 days after transplantation for the 2 rabbits,with fluorencently-labeled-EPCs.All of the rest remained rabbits were killed 4 weeks later for histological examinations.Results The histopathological slides showed that the fluorescence-positive expression existed in the injured endothelium 4 days after transplantation.At 4 weeks after the EPCs transplantation,there were less restenosis and less vascular wall thickening in the rabbits of cells transplantation group than those of the control group(P＜0.01).Conclusion The local interventional homografting heterogeneous endothelial progenitor cells can prevent restenosis after the carotid artery angioplasty in New Zealand White rabbit model. (J Intervent Radiol,2007,16:95-98)
