A preliminary clinical study on p53 gene in the therapy of advanced hepatocellular carcinoma
- VernacularTitle:动脉灌注p53基因治疗晚期肝癌的初步临床应用
- Author:
Shi-Xi CHEN
;
Jun CHEN
;
Wei-Dong XU
;
Guo-Wen YIN
;
Wei XI
;
- Publication Type:Journal Article
- Keywords:
p53 gene;
Hepatocelluar carcinoma;
Interventional
- From:
Journal of Interventional Radiology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily investigate curative effect of hepatic arterial perfusion of p53 gene in the therapy of advanced hepatocellular carcinoma.Methods Tirty cases of advanced hepatocellular carcinoma were divided into experimental group and control group,p53 gene was perfused into target artery confirmed by angiography.In experimental group,10~(12)Vp of p53 gene and 20 mg OPT were employed every week as a course for 21 days and 1 to 4 courses time the cases of the study.In control group,only 20 mg OPT was used.Results The survival period was 14 to 405 days in experimental group and 18 to 167 days in control group.There was a significant difference between the two groups(P＜0.05). Conclusion p53 gene is efficacious in the therapy of advanced hepatocellular carcinoma.(J Intervent Radiol,2007,16:127-129)
