Differences between the expression of matrix metalloproteinase-2.9 in preeclampsia and normal placental tissues
- VernacularTitle:基质金属蛋白酶与子痫前期发病关系的研究
- Author:
Jin-Ke LI
;
Qing XIONG
;
Shu ZHOU
;
Pei-Feng YANG
;
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Gelatinase A;
Gelatinase B;
Placenta;
Polymerase chain reaction
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the possible relationships between expression of matrix metalloproteinase(MMP)2,9 and the pathogenesis of preeclampsia in which trophoblast invasion is impaired. Methods MMP-2,9 expression were detected by immunohistochemistry streptavidin-biotin complex (SABC)method in 20 normal term placentae and 20 preeclampsia placentae,respectively.In addition, mRNAs for MMP-2,9 were analyzed by real time PCR in both groups.Results The intensities of both MMP-2 and MMP-9 immunostaining in preeclampsia placentae were significantly declined compared to those of normal term placentae(P
