Influence on the tumor after percutaneous intra-tumor injection of ~(32)P-GMS in liver cancer
- VernacularTitle:经皮瘤内注射~(32)P玻璃微球对肝癌组织的影响
- Author:
Jin-Sheng WANG
;
Xi-Cai CAO
;
Ya-Juan WANG
;
Zhi-Bing FAN
;
Fu-Xian JIANG
;
Yan HAN
;
Bin LI
;
Shi-Xin YAN
;
Jian TAN
;
Xiaodong WANG
;
- Publication Type:Journal Article
- Keywords:
Liver cancer;
~(32)P-GMS;
Injection of intra-tumor;
Pathology
- From:
Journal of Interventional Radiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence on the tumor after percutaneous intra-tumor injection of ~(32)P-GMS in liver cancer as well as its suitable dose.Methods 24 New Zealand rabbits were used to establish the animal model of VX-2 liver cancer,and divided into A,B,C and D groups with individually 37,74,111 and 148 MBq of ~(32)P-GMS being injected,respectively;and then pathological changes of tumor were observed by light and electron microscope respectively.Result The dose of ~(32)P-GMS was obviously correlated with the radioactivity damage of tumor cells.In the A and B groups,the tumor cells were not observed to disappear completely after injection of ~(32)P-GMS,but in C group,tumor cells were almost completely disappeared and surrounded by a lot of connective tissue.Although the tumor cells were found to disappear completely in D group,normal liver tissues were also involved.Conclusion Percutaneous intra-tumor injection of ~(32)P-GMS with suitable dose that may induce the tumor tissue to be maximally damaged and may also provide some significances to prevent the tumor metastasis.
