The effects of hyperbaric oxygen and free radical antagonists on liver fibrosis in chronic hepatitis patients
- VernacularTitle:高压氧联合自由基清除剂对慢性乙型肝炎肝纤维化指标的影响
- Author:
Ying-En LIU
;
Gong-En TANG
;
Jian-Fu WANG
;
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Hyperbaric oxygen;
Liver fibrosis;
Free radical antagonists
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of hyperbaric oxygen (HO) and free radical antagonists (FRA) on liver fibrosis (LF) in chronic hepatitis (CH) patients.Methods Seventy-two CH patients were ran- domly divided into a HO-FRA group (36 cases) and a control group (36 cases).The patients in the control group received routine treatment,while patients in the HO-FRA group were treated with hyperbaric oxygen,vitamin E and vitamin C.All patients' livers were examined ultrasonically,and liver function and blood fibrosis indices were meas- ured before and after the treatment.Results Compared with those in the control group,the concentrations of blood hyaluronic acid,laminin,precollagen and typeⅣcollagen were all significantly lower in the HO-FRA group.Ultra- sonic imaging showed that the main portal and the splenic vein diameter,and the length and thickness of the spleen had also significantly declined in the HO-FRA group after treatment.Conclusion HO and FRAs can nelp to stave off liver fibrosis as indicated by blood and ultrasonic fibrosis indices.
