The changes of the intercellular spaces of squamous epithelium of lower esophagus in gastroesophageal reflux disease
- VernacularTitle:胃食管反流病患者食管下段鳞状上皮细胞间隙的改变
- Author:
Yan XUE
;
Li-Ya ZHOU
;
San-Ren LIN
;
Yonghui HUANG
;
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux disease;
Dilated intercellular spaces;
Squamous epithelium
- From:
Chinese Journal of Digestion
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of the intercellular spaces of squamous epithelium of lower esophagus in gastroesophageal reflux disease(GERD).Methods Eleven outpatients with GERD symptoms more than 3 months [6 with nonerosive reflex disease(NERD)and 5 with erosive esophagitis(EE)]and 5 healthy volunteers were recruited.All of them underwent endoscopy and 24-hr ambulatory pH monitoring.Biopsies were taken in lower esophagus(2 cm above Z-line)for electron microscope examination.Results Intercellular spaces of esophageal epithelial cell in volun teers,NERD patients and EE patients were (0.374?0.073)?m,(1.308?0.079)?m and (1.332?0.144)?m respectively,with significant differences between the control group and the NERD or EE group.There was no difference between NERD group and EE group.Conclusions Dilated intercellular spaces were seen in both NERD and EE cases,which was significantly different from the control cases.
