Clinical manifestation of Wegener's granutomatosis
- VernacularTitle:韦格纳肉芽肿病11例临床特征分析
- Author:
Yun-Zhe SHI
;
Ri-Qiang LUO
;
Xiao ZHANG
;
- Publication Type:Journal Article
- Keywords:
Wegener's granulomatosis;
Therapy;
Manifestation of systems
- From:
Chinese Journal of Rheumatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Wegener's granulomatosis is a rare multisystem vasculitis of unknown aetiology. The clinical features of the disease,the treatment and long-term follow-up is observed in this study.Methods Eleven WG patients were from Rheumatology Department of Guangdong Province People's Hospital between 1999—2005.Data were obtained retrospectively.The patients' clinical manifestation and laboratory results were studied.Results All patients had upper and lower respiratory tracts involvement.The upper respiratory tract(nose,sinus,throat,trachea,and middle ear)-(E)lung(L),and kidneys(K)were the most commonly in- volved organs.The majority of patient received i.v.puls methylprednisolone 0.5 g/d?3 d,followed by oral pred- nisone 1 mg.kg~(-1).d~(-1)and i.v.pulses of cyclophosphamide 750 mg/m~2.The long-term outcome was good. Conclusion Wegner's granulomatosis is a systemic vasculitis occurring in patients with histopathologic mani- festation of necrotizing vasculitis with granuloma formation.Corticosteroid and immunosuppressive treatment may achieve good outcome.
