Two Cases of HLA-B59(+) Stevens-Johnson Syndrome (SJS)-Toxic Epidermal Necrolysis (TEN) Associated with Methazolamide Treatment.
- Author:
Kee Han SUNG
1
;
Yun JEONG
;
Hyung Uk CHOI
;
Sook Kyung LEE
Author Information
1. Department of Dermatology, Maryknoll Hospital, Busan, Korea. skh1009@korea.com
- Publication Type:Case Report
- Keywords:
Stevens-Johnson syndrome-Toxic epidermal necrolysis;
Methazolamide;
HLA-B59
- MeSH:
Asian Continental Ancestry Group;
Carbonic Anhydrases;
Histocompatibility Testing;
Humans;
Intraocular Pressure;
Methazolamide*;
Stevens-Johnson Syndrome*
- From:Korean Journal of Dermatology
2005;43(4):561-563
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Methazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous eyes. Stevens-Johnson syndrome (SJS)-toxic epidermal necrolysis (TEN) associated with methazolamide treatment has been reported in Korean and Japanese patients. We report two cases of SJS-TEN associated with methazolamide treatment. The result of HLA typing of our two patients was a positive reaction for HLA-B59, which is specific to Koreans and Japanese. This suggests a possible relationship between genetic background and SJS-TEN associated with methazolamide treatment. Therefore, methazolamide should be prescribed with caution to Korean or Japanese patients.
