Experimental Study of Total Flavonoids from Stems and Leaves of Scatellaria Baicalensis in Preventing and Curing Diabetes Mellitus
- VernacularTitle:黄芩茎叶总黄酮对糖尿病防治作用的实验研究
- Author:
Xiaoxia ZHOU
;
Peiqing SU
;
Zhi LIU
;
- Publication Type:Journal Article
- Keywords:
Total flavonoids from stems and leaves of scatellaria baicalensis;
Blood glucose;
Alloxan
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the hypoglycemic effect of total flavonoids from stems and leaves of scatellaria baicalensis (SSTF)on diabetic mice and to explore the therapeutic mechanism.Methods Diabetic mice models were established by intraperitoneal injection of alloxan(200 mg/kg),and the changes of mice blood glucose ,superoxide dismutase activity and malondialdelyde content were observed after preventive or curative treatment with SSTF.Results Preventive treat- ment with SSTF can obviously inhibit the increase of mice blood glucose induced by alloxan ,and the therapeutic treat- ment with SSTF can lower the blood glucose levels of diabetic mice.Both preventive and therapeutic treatment groups can increase serum superoxide dismutase activity and decrease malondialdelyde content.Conclusion SSTF have significant preventive and therapeutic effects on diabetic mice,and the mechanism is related to the anti-oxidation activity.
