Antidepressant Effects of Yiyukang in Mice and Rats
- VernacularTitle:抑郁康制剂的抗抑郁作用研究
- Author:
Wei ZHAO
;
Guojun HUANG
;
- Publication Type:Journal Article
- Keywords:
Yiyukang;
Depression;
Antidepressant
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antidepressant effect of Yiyukang and to explore its possible mechanism.Methods By using the mice forced-swimming models,mice tail suspension models and mice stereotyped behavior models,the antidepressant effect of Yiyukang and its mechanism were observed.Result In the mice forced-swimming test,the im- mobility-time was significantly reduced by high and medium dosage Yiyukang with the reduced rate being 21.65% and 24.84%(P＜0.01).The high dosage can also reduce the immobility time of tail-suspension mice with the rate of 29.58%(P＜0.01).Yiyukang can strengthen the mice head shaking behavior and had synergistic action with 5- HTP on reducing stereotyped behavior in mice.Conclusion Yiyukang has certain antidepressant effect,and the mecha- nism may be associated with promoting the actions of 5-hydroxytryptamine and dopamine in mice brain.
