Feasibility Study on Blood Concentration Determination of Peripiocoside in Bawei Jiangu Tablet by Chemiluminescence Enzyme Immunoassay
- VernacularTitle:化学发光酶免疫法测定八味健骨片中杠柳毒苷血药浓度的可行性研究
- Author:
Yingping CHEN
;
Yuan TIAN
;
Yi HAN
;
Bo HAN
;
Li GONG
;
Guoxin LI
;
Guifang LIU
;
Xuewen ZHOU
;
- Publication Type:Journal Article
- Keywords:
Bawei Jiangu Tablet;
Digoxin;
Periplocoside;
Pharmacokinetics
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the clinical pharmacokinetics research method for Bawei Jiangu Tablet.Methods Drug blood concentration was estimated through analyzing the ingredients and preclinical pharmaceutical research results of Bawei Jiangu Tablet.Results Corresponding cardiac glycoside value in serum of animals treated with oral use of Bawei Jiangu Tablets and cortex periplocae extracts can be detected by drug monitor system of digoxin immunoreaction, which was similar to that in animals treated with digoxin.Corresponding cardiac glycoside value had also been detetected in serum of subjects in phaseⅠclinical tolerance trial,which was related to the time and dosage of administration.Clini- cal negative control trial showed that the reaction was specific.Conclusion Pharmacokinetics study on target of toxic components with cross-reaction of periplocoside is feasible through drug monitor system of digoxin immunoreaction.
