Influence of Different Dosage Form on the Release Rate of Sustained-released Danshen Extract Preparations
- VernacularTitle:不同剂型结构对丹参提取物缓释剂释放度的影响
- Author:
Yuanxin LI
;
Xujiang YUAN
;
Shengshan ZHU
;
- Publication Type:Journal Article
- Keywords:
Dosage form;
Sustained-released Danshen extraction preparations;
Release rate
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of different dosage forms on the release rate of total salvianolic acid of sus- tained-released Danshen extract preparations.Methods With salvianolic acid B as the standard,uhraviolet spec- trophotometry and the release test were applied to determine the accumulated release rate of total salvianolic acid of sus- tained-released Danshen extract preparations(R1～R9)of 9 different dosage forms and to evaluate the release behav- ior of sustained-released Danshen extract preparations in vitro.Results The accumulated release rate of total sal- vianolic acid in R7 was the best,and the in vitro release behavior was consistent with Higuchi equation:M_1/M_∞= 0.363 4t~(1/2)-0.1656,r= 0.996 2.Conclusion R7 is the first choice dosage form for the preparation of the sus- tained-released Danshen extraction preparations.
