D-Penicillamine induced nephrotic syndrome and myasthenia gravis:two cases report and review of literature
- VernacularTitle:青霉胺致肾病综合征重症肌无力二例并文献复习
- Author:
Hui-Qin HAO
;
Feng HUANG
;
Wei ZHAO
;
Qian-Xun ZHAI
;
- Publication Type:Journal Article
- Keywords:
Pencillamine;
Adverse effect;
Literature review
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve clinicians'understanding of nephrotic syndrome and myasthenia gravis as adverse events of penicillamine(D-PA).Methods Two patients were reported to develope adverse reaction after taking D-PA.The related literature were reviewed.Result The first case was a systemic sclero- sis(SSc)patient treated with D-PA who developed nephrotic syndrome and blepharoptosis.The second case was a rheumatoid arthritis patient treated with D-PA who developed dysphagia and drinking bucking.The clinical symptoms were improved after disconting D-PA.Their conditions were stable up to now.Conclusion D-PA is used widely for various of autoimmune diseases.Clinicians should pay attention to these special and rare adverse effects.
