Comparisons of clinical characteristics of primary Sj gren's syndrome onset at different ages
- VernacularTitle:不同年龄发病的原发性干燥综合征的免疫学异常及临床特点的比较
- Author:
Zhong-Qiang YAO
;
Li LONG
;
Zhan-Guo LI
;
- Publication Type:Journal Article
- Keywords:
Sj ngren syndrome;
Age of onset;
Comparative study
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the difference in clinical characteristics and experimental profiles of primary Sj gren's syndrome(pSS)with a different onset age.Methods The clinical and laboratory data of 136 pSS patients were retrospectively analyzed.Results The prevalence of anti-SSA and anti-SSB antibodies de- clined with later onset.As compared with patients with disease onset older than 45,patients with disease onset younger than 45 had higher rheumatoid factor,circulating immune complex and lower C3.The prevalence of parotitis was higher in patients with disease onset younger than 45 than those with disease onset older than 45. The two groups had similar extra-glandular involvement.Conclusion The younger onset pSS patients have more abnomlalities in inmmnological parameters,and more parotiditis,implying that young onset pSS have more strong immune responses.
