The effects of electroacupuncture on the expression of insulin like growth factor 1 in the hippocampal CA1 region after ischemia-reperfusion
- VernacularTitle:电针对脑缺血再灌注大鼠海马区胰岛素样生长因子-1表达的影响
- Author:
Li-Hong KONG
;
Qing-Ju MAO
;
Bang-Guo CHEN
;
Zhen-Guo JIN
;
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Electroacupuncture;
Hippocampus;
Apoptosis;
IGF_1
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of electroacupuncture on cell apoptosis(CA)and the ex- pression of insulin like growth factor 1(IGF_1)in the hippocampal CA1 region of rats'brains after cerebral ischemic- reperfusion(CIR).Methods Middle cerebral artery obturation(MCAO)was established by the suture embolic method.CA and the expression of IGF_1 in the hippocampal CA1 region were detected by immunohistochemical meth- ods and TUNEL staining,respectively.Results Compared with those in the normal and sham operation groups, apoptotic cells were significantly increased in the hippocampal CA1 region of the model group(P＜0.01),while the expression of IGF_1 was slightly enhanced and plasma staining was also slightly positive(P＜0.05).Apoptotic cells in the CA1 region in the electroacupuncture group were obviously fewer in comparison with the normal group(P＜0.01),while the expression of IGF_1 was distinctly increased and the plasma staining was also obviously positive(P＜0.01).Conclusion Electroacupuncture treatment has preventive and therapeutic effects on ischemia-reperfusion injury,and its mechanism might be related with up-regulating the expression of IGF_1 and inhibiting CA.
