Improvement effects of berberine on glycated brain damages in rats induced by D-galactose
- VernacularTitle:小檗碱对D-半乳糖诱导糖基化大鼠脑损害的干预作用
- Author:
Jun-Hua LV
;
Shi-Ping ZHANG
;
Hao ZHENG
;
- Publication Type:Journal Article
- Keywords:
berberine;
D-galactose;
glycation;
calcium ion;
mitochondria
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the improvement effects of berberine on glycated brain damages in model rats induced by D-galactose. METHODS: The model rats of protein glycation were induced by intraperitoneal administration of D-galactose(150 mg/kg?d) for 8 weeks,and all rats were treated with berberine(high dose 300 mg/kg,middle dose 150 mg/kg,low dose 75 mg/kg) for 6 weeks.The activity of aldose reductase in red blood cells,the amount of glycated products(fructosamine in serum,glycohaemoglobin,advanced gtycation end-products),and the content of AGEs in brain tissue,calcium ion in brain cells were measured.Moreover,mitochondria in brain hippocampus cells were observed under electronic microscope. RESULTS: High dose and middle dose of berberine could decrease the activity of aldose reductase in red blood cells(P
