The relationship between the exon 4 gene polymorphism of TIM-1 and rheumatoid arthritis
- VernacularTitle:TIM-1外显子4基因多态性与类风湿关节炎关系的研究
- Author:
Rong-Hong MA
;
Tian-Pen CUI
;
Li-Hua HU
;
- Publication Type:Journal Article
- Keywords:
Arthritis;
rheumatoid;
T cells immunologlobulin domain and mucin domain protein-1;
Anti-keratin antibody;
Gene polymorphism
- From:
Chinese Journal of Rheumatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the exon 4 gene polymorphism of TIM-1 and rheumatoid arthritis (RA) in Han population from Hubei province.Methods Polymerase chain reaction was used to detect the ins/del polymorphism of the exon 4 of TIM-1 from RA population and the normal con- trols.Rheumatoid factor (RF),anti-cyclic citrullinated peptide (CCP) antibody and anti-keratin antibody (AKA) were also detected.Results Two alleles,a wild type del and a variant allele ins were identified in the TIM-1 exon 4.The genotype frequencies of del/del,ins/del and ins/ins were 0.650,0.280 and 0.070 respec- tively in the normal controls and 0.616,0.302,0.082 respectively in RA population.There was a significant correlation between the positive ratio of AKA and the genotypes of the exon 4.Conclusion The polymorphism of the exon 4 of TIM-1 is not associated with rheumatoid arthritis in Han population from Hubei Province of China.The genotypes of the exon 4 may have an effect on the expression of AKA.
