Effects and the mechanism of high volume hemofiltration on acute lung injury induced by endotoxin in dogs
- VernacularTitle:高容量血液滤过对内毒素诱导犬急性肺损伤的治疗作用
- Author:
Fen LIU
;
Zhenguo ZENG
;
Rong JIANG
;
Feng ZHU
;
Cheng NIE
;
Kejian QIAN
;
Nonghua LV
;
- Publication Type:Journal Article
- Keywords:
High volume hemofiltration;
Endotoxin;
Acute lung injury;
Mechanism
- From:
Chinese Journal of Emergency Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the treatment effect and the mechanism of high volume hemofiltration(HVHF)on acute lung injury(ALl)induced by endotoxin in dogs.Methods Sixteen healthy hybrid male dogs were injected LPS(650?g/kg)via central vein within 30 minutes.After model establishment,all animals were divided into two groups randomly( n=8).One group received the treatment of HVHF,while another group received routine treatment.PH,PaO_2,PaCO_2 in arterial blood were recorded at O h after LPS model establishment and 4h after HVHF.Contents of TNF-?,IL-6,and IL- 10 in plasma were measured by radioirnmunity,mRNA expression of TNF-?,IL-6,and IL-10 in lung tissue homogenate were measured by RT-PCR and NF-?B activity by flow cytometer.Results After injection of LPS,PaO_2 and PaO_2/FiO_2 began to decrease,and PaO_2/FiO_2 value was
