Effect of inhaling penehvclidine hydyochloride in treatment of patients with acute exacerbation of chronic obstrnctive pulmonary disease
- VernacularTitle:雾化吸入盐酸戊乙奎醚在慢性梗阻性肺疾病急性发作治疗中的作用
- Author:
Rongsheng MIAO
;
Bing YANG
;
Xueping HUANG
;
- Publication Type:Journal Article
- Keywords:
Penehyclidine hydyochloride;
Chronic obstructive pulmonary disease;
Acute exacerbation;
Lung function;
Pulmonary arterial pressure
- From:
Chinese Journal of Emergency Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficiency of inhaling penehyelidine hydyoehloride(PHC)in reducing pulmonary arterial pressure and improving lung funetion in patients with acute exaeerbation of ehronie obstruetive pulmonary disease(AECOPD).Methods Sixty patients with AECOPD were randomly divided into the control group(30 patients) and the treatment group(30 patients).The patients in treatment group inhaled PHC,and patients in control group inhaled diprophylline.The pulmonary arterial pressure was measured before and after inhalation.The peak expiratory flow(PEF) and forced expiratory volume in one second(FEV1)was measured at different time points before and after inhalation. Arterial blood gas and,symptoms were also observed.Results The pulmonary arterial pressure in treatment group was reduced by 20% and reduced by 5% in the control group.FEV1 and PEF were improved after inhalation,the average increase of FEV1 was 350 ml(P＜0.01),and PEF was improved by 37 L/min(P＜0.05).Arterial blood gas analysis was improved,and PaO_2 increased by 18 mmHg(P＜0.01).The respiratory rate and the symptoms of cough and sputum were also improved.Conclusion PHC improved the lung function of patients with AECOPD by reducing the pulmonary arterial pressure.
