Mild hypothermia reduces and delays cell apoptosis in the hippocampal CA_1 region following ischemia-reperfusion injury
- VernacularTitle:亚低温减少和延迟缺血再灌注后沙土鼠海马CA_1区细胞凋亡
- Author:
Fu-Sheng ZHANG
;
Gang ZHANG
;
Rui-Guo DONG
;
- Publication Type:Journal Article
- Keywords:
Mild hypothermia;
Apoptosis;
Bax;
Cytochrome C
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of mild hypothermia on cells in the CA_1 region of the hippocampus in gerbils following global ischemia-reperfusion injury(IRI),and to explore their mechanism. Methods IRI models were established in 75 gerbils.Any changes in TUNEL positive cells and the expression of Bax and Cytochrome C were then observed in normothermic(N) ,hypothermic(H)and sham(S) groups through immu- nohistochemistry methods.Results In the H group(as compared with the N group)apoptotic cells in the CA_1 sub- field of the hippocampus significantly decreased.The expression of Bax and Cyt C at 3 h,6 h and 1 d were de- creased,and the expression fastigium was delayed.Conclusion Mild hypothermia can moderate and delay cell ap- optosis,and its mechanism might be related with reducing and delaying the expression of Bax and Cyt C released by mitochondria.
