The effects of ultraviolet blood irradiation and oxygenation on oxygen free radical metabolism in rabbits with soman intoxication
- VernacularTitle:紫外线照射充氧自血回输对梭曼中毒家兔氧自由基代谢的影响
- Author:
Xian-Qing ZHANG
;
Xiao-Di ZHANG
;
Shi-Jie MU
;
Xing LIANG
;
Ai-Jun XIA
;
Chun-Xu HAI
;
- Publication Type:Journal Article
- Keywords:
Ultraviolet blood irradiation;
Blood oxygenation;
Soman intoxication;
Oxygen free radicals
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ultraviolet blood irradiation and oxygenation(UBIO)on oxygen free radical metabolism(OFRM)in rabbits with acute soman intoxication.Methods One hundred rabbits were randomly divided into five groups:a control group,a soman intoxication group(I),a soman intoxication plus routine therapy group(TR),a soman intoxication plus UBIO therapy group(UBIO)and a soman intoxication plus complex therapy group(CT).All the rabbits were intervened accordingly.Then the concentrations of malondiade- hyde(MDA)and the activities of superoxide dismutase(SOD),glutathionperoxidase(GSH Px)and catalase (CAT)in serum were determined at 14 d after various treatments.Results Compared with the control group,the concentration of MDA and the activity of CAT in the 1 group were significantly increased(P＜0.01),while the activi- ties of SOD and GSH Px were obviously decreased(P＜0.05).After UBIO or complex therapy,the serum level of MDA was significantly decreased in comparison with that in the I group(P＜0.01),while the concentrations of SOD, GSH Px and CAT were enhanced(P＜0.05).Conclusion UBIO therapy can improve antioxidation activity against the injury caused by free radicals and could be used to treat acute soman intoxication,which causes injury from in- creased oxygen free radical concentrations.
