Expression of netrin-1 in placenta from patients with pre-eclampsia and the relation to placental angiogenesis
- VernacularTitle:轴突导向因子netrin-1在子痫前期患者胎盘组织中的表达及其与胎盘新生血管形成的关系
- Author:
Yun YANG
;
Li ZOU
;
Ke-Shu XU
;
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Placenta;
Neovescularization,pathologic;
Nerve growth factors;
Tumor suppressor proteins
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of netrin-1 in placenta from patients with pre- eclampsia and the relation to placental angiogenesis.Methods Twenty patients with pre-eclampsia(12 mild cases and 8 severe cases)and 20 normal late pregnant women were investigated.The expression of netrin-1 mRNA and protein was determined with RT-PCR and Western blotting respectively.The placenta vascular density was examined by immunohistochemical F8 staining.Results (1)The values of netrin-1 mRNA in normal group and pre-eclampsia groups were 0.51?0.08 and 0.41?0.06;The values of netrin- 1 protein in normal group and pre-eclampsia groups were 26.4?1.8 and 20.5?1.3(P
