Expression and effect of secondary lymphoid tissue chemokine in experimental ulcerative colitis in rats
- VernacularTitle:次级淋巴组织趋化因子在实验性大鼠溃疡性结肠炎中的表达及意义
- Author:
Xi-Mei CHEN
;
Bu-Jun GE
;
Chang-Qing YANG
;
Jian WU
;
- Publication Type:Journal Article
- Keywords:
Secondary lymphoid tissue chemokine;
Ulcerative colitis;
Expression
- From:
Chinese Journal of Digestion
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and effect of secondary lymphoid tissue chemokine(SLC)in experimental ulcerative colitis(UC)in rats.Methods Thirty Spague-Dawley rats were divided into control group and UC group.SLC expression in colon tissues was detected by RT-PCR and immunohistochemistry,respectively.Results The transcriptional level of SLC in UC tissues was significantly higher than that in the control group(0.846?0.07 vs 0.312?0.12,P＜0.01).The positive expression of SLC was concentrated mainly on submucosa,and the positive rate of SLC protein expression in UC group significantly higher than that in control group(P＜0.01).Conclusion SLC overexpression could contribute to the pathological processes in UC rats,thus SLC may be an ideal ther- apeutic target for UC.
