Expression of liver receptor homolog 1 gene in patients with cholesterol gallstone disease
- VernacularTitle:胆囊胆固醇结石患者肝脏受体类似物1基因表达差异的研究
- Author:
Shi-Yong YANG
;
Tian-Quan HAN
;
Zhao-Yan JIANG
;
Qu CAI
;
Hai HU
;
Zhihong JIANG
;
Zuobiao YUAN
;
Xingxing CAI
;
Shengdao ZHANG
- Publication Type:Journal Article
- Keywords:
Cholesterol gallstone disease;
Liver receptor homolog 1;
Gene expression
- From:
Chinese Journal of Digestion
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mRNA expression of liver receptor homolog 1 (LRH-1) gene in patients with cholesterol gallstone disease so that to elucidate the biomolecular pathogenesis of gallstone for- mation.Methods Twenty-seven patients with cholesterol gallstone (CGS) and 14 controls were included in this study.Biliary composition was assayed and mRNA expression of hepatic LRH 1 gene was determined by real time polymorphism chain reaction.Results In CGS patients,expression of LRH-1 was significantly higher than that in controls (14.18?9.37 vs 7.86?6.19,P＜0.05),and cholesterol of bile was oversaturated (1.17?0.27).Conclusion The formation of CGS may be related to increased expression of hepatic LRH-1 gene.
