Immunohistologic analysis of renal peroxisome proliferator-activated receptor?expression in lupus nephritis patients
- VernacularTitle:PPAR?在狼疮肾炎患者肾组织中的表达及其意义
- Author:
Ya-Jie ZHANG
;
Xiao YANG
;
Wei-Ying CHEN
;
Wen-Xing PENG
;
Wei-Ming GUAN
;
Xiao-Yan LI
;
Xue-Qing YU
;
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Peroxisome proliferator activated receptors;
Kidney
- From:
Chinese Journal of Rheumatology
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of peroxisome proliferator-activated receptor (PPAR?)in lupus nephritis(LN)patients and the possible mechanisms of PPAR?in the pathogenesis of LN. Method PPAR?expression was examined in 21 LN patients and 5 normal kidney biopsy specimens by im- munohistochemical method.The relationship between PPAR?expression and renal pathologic changes was an- alyzed.Results Glomerular and tubular positive staining of PPAR?in LN patients was markedly up-regulated compared with that in normal kidney specimens.The distribution and expression of PPAR?in classⅣwas sig- nificantly increased compared with that in classⅤandⅡ.The relevance assay showed that there was positive relationship between active index and glomerular PPAR?immunohistochemistry staining cell numbers(r=0.94, P＜0.01 ).Conclusion This study demonstrates in vivo that PPAR?expression is increased in active LN pa- tients with pathological active inflammation.These data suggest that the increase of PPAR?expression in renal cells may play an important role in the pathogenesis of LN.
