Influence of gender differences on nuclear factor-kappa B activation in livers in septic rats
- VernacularTitle:性别差异对脓毒症大鼠肝脏核因子-kB活化的影响
- Author:
Xiaohui DU
;
Yongming YAO
;
Rong LI
;
Chuan'An SHEN
;
Huinan YIN
;
- Publication Type:Journal Article
- Keywords:
Sepsis;
Neuclear factor-kappa B;
Tumor necrosis factor-?;
Liver
- From:
Chinese Journal of Emergency Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of gender differences on NF-kB activation in livers in septic rats. Methods Total 20 female and 20 male Wistar rats were randomly divided into four groups.Tissue samples of the livers were collected to measure NF-kB activation by EMSA.The level of plasma ALT,TNF-?and estrogen were measured also. Results NF-kB activation in normal male and female rats has no significant difference (P＞0.05).After stimulated by LPS,the level of NF-kB activation and ALT,TNF-?in plasma were markedly upregulated,and the index of female group lower than that in male group (P＜0.01).The level of NF-kB activation in livers and ALT,TNF-?in plasma both in male and female have significantly negative correlation with the level of estrogen in plasma (P＜0.05 ).Conclusion There are significantly gender differences on NF-kB activation in livers in septic rats.Estrogen may decrease the injury of livers in septic rats.
