The hemoprotective effects of a rotary magnetic field in mice exposed to?irradiation
- VernacularTitle:旋转磁场对放射损伤小鼠造血保护作用的研究
- Author:
Bai-Miao JI
;
Guo-Li SONG
;
Xiao-Yun ZHANG
;
- Publication Type:Journal Article
- Keywords:
Rotary magnetic field;
Radiation injury;
Bone morphogenetic proteins;
Hemoprotection
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the hemoprotective effects of a rotary magnetic field(RMF)with radiation- injured mice.Methods C57 BL6/J mice were randomly divided into a control group and a magnetic treatment group.The mice received total body irradiation with 7.0 Gy and 6.5 Gy ~(137)Cs?rays.The treatment group was trea- ted with a RMF for one hour at a time,twice a day.The intensity of the RMF was 0.6T.The survival rate was ob- served for 30 days.On day 7,10,14,21,28 after irradiation,the subjects' peripheral blood cells were counted.On day 12 and 16,the number of bone marrow mononuelear cells(BMNCs)was measured and their ability to form granu- locyte-macruphage colony-forming unit(CFU-GM)was assessed.The pathological sectioning of the femur was per- formed and the expression level of bone morphogenetic proteins(BMPs)in the bone marrow were evaluated.Re- sults The RMF treatment increased the survival rate and duration among the irradiated mice and the number of blood cells in their peripheral blood.Also,RMF treatment could increase the number of BMNCs and improve their ability to form CFU-GM on days 12-16.Furthermore,RMF could improve angiogenesis and the expression level of BMPs. Conclusion The RMF treatment had an obvious protective effect against the effects of irradiation,and it accelerated the recovery of hematopoiesis and the hematopoietic microenviroment in mouse bone marrow.
